BDNF human Carrier free, recombinant, expressed in E. coli, =95% (SDS-PAGE), suitable for cell culture

General description

The gene BDNF (brain derived neurotrophic factor) is mapped to human chromosome 11p14.1.[1] BDNF is a member of the neurotrophin family of growth factors.[2][3] The gene encodes a precursor protein, proBDNF. Mature BDNF (mBDNF) is synthesized by post-translational cleavage of proBDNF. Both proBDNF and mBDNF play crucial roles in cellular signaling.[4] BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0kDa homodimer of two 119 amino acid subunits linked by strong noncovalent interactions.